Our Research

Most of the primary functions of the body can be traced down to the spatial organisation and interactions of biomolecules such as proteins and nucleic acids in cells of the heart, central and periopheral nervous system, and tumours. We study signalling proteins in their spatial organisation, chemical configuration, and their communication with partnering molecules in situ. Studying these features of individual and groups proteins in their native environment gives us a unique window into the fundamental rules of life, health, and disease. To visualise these biomolecules with the highest precision we leverage optical super-resolution microscopy techniques such as localisation microscopy and expansion microscopy.

Our Projects

We currently work on a number of research and technology questions. What are the networks of molecules that regulate the calcium signals that drive the heartbeat? What is the 3D organisation of molecules in signalling domains on the surfaces of neurons? What are the components of the molecular machinery that regulate the shape and sizes of membrane-bound organelles and vesicles in tumour cells? We also work on developing new biomedical research tools. These include new, hydrogel-based expansion microscopy protocols that allow us to physically inflate cells, AI-based tools to recognise patterns in our image data, data validation frameworks and scientfic simulations. So, whether you are a life or biomedical scientist, or more interested in the physics, engineering or the tech, we will have projects that will interest to you.

Our Team

Our team is a diverse group of biomedical and biophysical scientists and engineers. We are from all walks of life, with different skills and experiences that come together to make our science possible. Equity, diversity, inclusion, and accessibility are at the heart of how we work. We constantly model, share, and learn about making our workplace inclusive and a place where the future of science is shaped.